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396,397 Interventions for Ulcerative colitis The progression of UC is a complex process that is attributed primarily to genetics and the environment and secondarily to a disturbance of the gut microbiota, 398,399 abnormal immunoregulation, 400 and psychological stress

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There are various causes of leaky gut syndrome, including often-overlooked small intestine bacterial overgrowth (SIBO), mast cell activation syndrome, and mold illness